Over 95% of the animals we rely on for medical advances are rodents and most of them live, and are studied, in stressful environments that compromise our ability to learn from them. Investigations by animal welfare scientists reveal that research rodents are typically CRAMPED: Cold, Rotund, Abnormal, Male-biased, Poorly surviving, Enclosed, and Distressed. And it has been suggested that this may partly explain why studies with rodents don’t translate as well as they could to bring us the medical treatments we and our loved ones are hoping for. But can we do better? Our guest today is Dr. Harry Knot, once a researcher and IACUC member himself, who is currently the CEO of TSE Systems. He is completely convinced that we CAN do better and he will share some innovative solutions for how…on GetReal!

CRAMPED mice skew research findings

‘Shoebox’ Lab Cages Impair Animal Health, Affect Health Research Results

Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis

“Control” laboratory rodents are metabolically morbid: Why it matters

Enriched Environment-induced Maternal Weight Loss Reprograms Metabolic Gene Expression in Mouse Offspring

TSE Systems: three unique instruments designed around solving some of the challenges of Time, Stress, Bias, Reproducibility, and Animal Welfare.

Intellicage

Check out the JOVE video here!

Paper: IntelliCage as a tool for measuring mouse behavior – 20 years perspective

Paper: The IntelliCage System: A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder

PhenoWorld

Paper: PhenoWorld: a new paradigm to screen rodent behavior

Paper: Social interactions impact on the dopaminergic system and drive individuality

Stellar Telemetry

Paper: Metabolic and Cardiovascular Benefits and Risks of EMD386088-A 5-HT 6 Receptor Partial Agonist and Dopamine Transporter Inhibitor